The Italians entered the match at Old Trafford brimming with confidence. They had dominated United for most of the first leg at the Stadio Olimpico in a match that ended 2-1, but could have been much worse for the English side, who also saw midfielder Paul Scholes sent off in the first half of that match after receiving two yellow cards.
United, however, quickly dispelled any notions that they were going to roll over in the second leg, as midfielder Michael Carrick and forwards Alan Smith and Wayne Rooney scored three early first-half goals in quick succession (Carrick 12', Smith 17', Rooney 19'). Stunned, Roma pushed forward in attack, only to leave their defense exposed. Cristiano Ronaldo took advantage of the space, scoring goals on either side of the break (44', 49') to push the lead to 5-0.
Carrick completed his brace with a 60th-minute rocket to make it 6-0 before Roma finally drew blood with a 69th-minute shot from Daniele de Rossi. Roma's humiliation was complete in the 81st minute, as United back Patrice Evra knocked a low shot past keeper Doni to complete the final scoreline of 7-1.
The win set up a semifinal match-up against AC Milan, who beat United 3-5 on aggregate on their way to winning their seventh European Cup/Champions League title.